Kenneth L. Tyler MD

University of Colorado School of Medicine

Dr. Tyler is a cum laude graduate of Harvard University and received his M.D. from Johns Hopkins. He trained in internal medicine at the Brigham and in neurology, including serving as Chief Resident, at the MGH. He completed a fellowship in Microbiology & Molecular Genetics with the late Dr. Bernard Fields at Harvard Medical School. He left the faculty at Harvard to join the University of Colorado School of Medicine in 1991, and became Chair of the Department in 2009. Dr. Tyler is also a Professor of Medicine (Infectious Disease) and Immunology-Microbiology and the Co-Director of the School of Medicine’s Center for Neuroscience (“CNS”). Dr. Tyler is an internationally recognized authority on infections of the nervous system. He has authored over 250 papers and reviews and edited several books. As a research scientist he has made seminal contributions towards understanding the molecular pathogenesis of viral infections. His contributions include identifying viral genes involved in determining pathways of viral spread to the CNS, characterizing the role of defined components of the host’s immune response in the protection against CNS infection, and identifying key cellular pathways involved in mediating virus-induced neural cell death and developing novel animal models to study CNS viral infections including those caused by West Nile and EV-D68. His clinical contributions include identifying the etiologic role of herpes simplex virus in recurrent (Mollaret) meningitis, reporting the first case of natalizumab-associated PML, and characterizing the neurological manifestations of West Nile virus infections and more recently of EV-D68-associated acute flaccid myelitis. Dr. Tyler is a member of the Association of American Physicians (AAP), the American Society for Clinical Investigation (ASCI) and is a Fellow of the American Association for the Advancement of Science (AAAS). He has served on the American Academy of Neurology’s (AAN) Board of Directors and as Chair of their Membership Committee. He is currently the Treasurer of the American Neurological Association, and was a Director (2011-14). He was a Director of the Association of University Professors of Neurology (AUPN)(2014-17). He is a past Chair of the NIH’s Clinical Neuroimmunology & Brain Tumors (CNBT) Study Section and of Zika virus related Special Emphasis Panels. He serves as an Associate Editor of the Journal of Neurovirology and is currently on the Editorial Boards of Annals of Neurology, Neurology, JAMA Neurology, Experimental Neurology, Journal of Virology and Journal of Infectious Disease among others. Among his Awards and Honors are the S. Weir Mitchell and Lawrence McHenry Awards of the AAN. He has served as the Boshes Lecturer at Northwestern, the Landau Lecturer at Washington University in St. Louis, the Friedlander Lecturer at the University of Nebraska, the Connell Lecture in Canada, the Brendel Trust Lecturer in New Zealand, , the Richhmond Paine lecturer at Children’s National Medical Center, and the inaugural H. Richard Tyler lecturer at the Brigham. .

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