Katrin I. Andreasson MD
Dr. Andreasson is a physician-scientist studying mechanisms of neurodegeneration in the Department of Neurology and Neurological Sciences at the Stanford University School of Medicine. A principal focus of our research is the investigation of cellular and molecular mechanisms of neurodegeneration in acute and chronic neurological disorders, with an emphasis on understanding immune mechanisms contributing to disease onset and progression. One focus of the laboratory has been to understand the mechanistic basis by which inhibition of the COX/prostaglandin pathway by non-steroidal anti-inflammatory drug (NSAIDs) prevents development of common neurodegenerative disorders like Alzheimer’s and Parkinson’s diseases; these studies have led to the identification of the inflammatory PGE2 EP2 receptor as a major suppressor of beneficial myeloid responses in models of neurological diseases. More recently, systems biology approaches targeting brain microglia have identified novel immune pathways that are active in both chronic and acute models of brain injury. The examination of these pathways, in particular the immune kynurenine pathway had drawn the laboratory into studies of immune cell metabolism as a determinant of maladaptive immune responses in the brain. A primary objective of the laboratory is to understand how immune responses contribute to disease and to translate these findings to help patients with brain disorders.