Andrew J Cole MD, FRCP©

Massachusetts General Hospital and Harvard Medical School

Andrew J. Cole, MD, FRCP(C), is Professor of Neurology at Harvard Medical School and Director of the MGH Epilepsy Service, Chief of the Division of Clinical Neurophysiology and Vice-Chair of Neurology at Massachusetts General Hospital in Boston. Dr. Cole graduated magna cum laude from Dartmouth College and Dartmouth Medical School in Hanover, New Hampshire. He was a resident and chief resident in neurology at the Montreal Neurological Institute, McGill University, Montreal, Quebec. He served as Assistant Professor of Neurology at Johns Hopkins in Baltimore before moving to Massachusetts General Hospital where he has been since 1992. At MGH he oversees a large Epilepsy Clinic, a busy Epilepsy Surgery Program, and an Epilepsy and Clinical Neurophysiology Fellowship program that has trained over 75 fellows under his directorship. He has had NIH funding to support basic research on the consequences of abnormal neuronal activity, and he has been a Principle Investigator on numerous NIH and industry supported clinical trials of drugs and devices in epilepsy. He is the Founding Chair of the American Epilepsy Society Translational Research Committee and the Founding Associate Editor of Annals Clinical and Translational Neurology. He has authored over 150 papers, chapters and abstracts on epilepsy and cellular and molecular correlates of neuronal activity and has been an organizer, discussant or invited speaker at many national and international meetings. In the field of epilepsy he is considered expert in the evaluation and surgical treatment of patients with refractory epilepsy. He is credited with focusing attention on the role of immediate early gene expression after seizures and in association with synaptic plasticity, developing the “two-hit” hypothesis of epileptogenesis, identifying a role for Nerve Growth Factor Receptor-bearing neurons in protecting against seizure-induced neuronal injury during development, improving the application of modern neuroimaging tools, including high field strength anatomic scanning and peri-ictal imaging, in patient care, and advancing the surgical treatment of highly refractory focal status epilepticus. Most recently he has pioneered use of responsive neurostimulation in refractory idiopathic generalized epilepsy, provided proof of principle supporting development of a novel drug for status epilepticus, and demonstrated the occurrence of cryptic seizures in mesial temporal structures of patients with Alzheimer’s Disease.