Vascular Contributions to Neurodegeneration

Date/Time: Sunday, October 21, 2018 - 9:15 AM to 11:15 AM
Type: Plenary
Area: Dementia and Aging
Room: Centennial III & IV

Session Overview

Chair: Rebecca Gottesman, MD, PhD – Johns Hopkins University Co-Chair: Costantino Iadecola, MD - Weill Cornell Medicine A growing body of evidence indicates that vascular factors play a role in Alzheimer's disease (AD) and other neurodegenerative disease. Whereas clinical-pathological studies have demonstrated that vascular and neurodegenerative pathology coexist in over 50% of clinically-diagnosed AD, midlife vascular risk factors have emerged as important contributors to AD risk later in life. At the same time, basic science investigations have revealed a deleterious impact of Abeta and tau on neurovascular function and have unveiled previously-unappreciated pathways through which vascular dysfunction promotes neurodegenerative pathology. These recent developments have rekindled the view that vascular factors are critically important for cognitive health, but their impact on the overall dementia landscape, still dominated by AD pathology, remains unclear. Therefore, a symposium exploring the basic and clinical aspects of the interaction between vascular and neurodegenerative pathology may be of interest to the neurological community at large. To this end, we propose four talks by leaders in the field addressing relevant neurobiological, clinical and imaging aspects of the vascular-neurodegenerative overlap in AD and its potential for prevention and therapy.

Objectives

  • Recognize imaging markers which might identify cases in which there is a vascular contribution to dementing illness.

  • Describe potential mechanisms by which vascular risk factors might impact cognitive status.

  • Identify potential areas for prevention and treatment and estimate their effect on dementia prevalence and trends over the coming decades.