Presidential Symposium - Lewy Body Dementia: From Symptoms to Synuclein

Date/Time: Monday, October 22, 2018 - 9:15 AM to 11:15 AM
Type: Plenary
Area: Dementia and Aging
Room: Centennial III & IV

Session Overview

Chair: David M. Holtzman, MD - Washington University in St. Louis
Co-Chair: William T. Dauer, MD - University of Michigan Medical School

Lewy body dementia (LBD) is the second most common type of degenerative dementia and encompasses dementia with Lewy bodies and Parkinson disease dementia. Principle features of LBD include hallucinations, fluctuations in consciousness, sleep dysfunction and a close association with parkinsonism. The pathological hallmark of LBD is synuclein-containing Lewy bodies in the cerebral cortex that are similar in appearance to those that occur in Parkinson disease (PD). In LBD, Lewy bodies are frequently accompanied by other protein aggregates such as amyloid-β. Little is understood about the pathogenesis of LBD, including the cause of synuclein accumulation in cerebral cortex, its spread through the brain, how synuclein leads to neuronal dysfunction, and the relationship of LBD to PD. The speakers in this Symposium will present the latest research in these areas, advancement of which is critical to advancing novel therapies for DLB.

Objectives

  • Recognize the cardinal clinical features of LBD, including its varied presentations.

  • Understand the proper use of laboratory and neuroimaging studies in the diagnosis of LBD.

  • Appreciate current scientific knowledge about how synuclein accumulates and disrupts neuronal function.