Advances in Cell-based Therapies for Neurological Diseases

Date/Time: Tuesday, October 23, 2018 - 8:45 AM to 10:45 AM
Type: Plenary
Area: Neurotherapeutics/Cellular
Room: Centennial III & IV

Session Overview

Chair: M. Elizabeth Ross, MD, PhD – Weill Cornell Medicine
Co-Chair: Jack M. Parent, MD – University of Michigan Medical School

Recent proof-of-principle studies of cell-based therapy are leading to approaches currently in or nearing early phase clinical trials. This symposium presents several of the approaches under investigation and initial data suggesting this may constitute an effective therapeutic strategy in the near future. Speakers will present pre-clinical and early phase cell-based clinical trial data for the treatment of several neurological disorders. Included will be use of genetically engineered autologous or heterologous stem cells engineered through gene delivery or genome editing. Discussion will include the challenges and early responses to these approaches and provide informed projections regarding the near future applications of these technologies.

Objectives

  • How to differentiate the cell types from stem cells (embryonic or induced progenitor) that would be useful.

  • At what stage of differentiation should cells be transplanted.

  • Whether to use heterologous cells that would require immunosuppression long term or whether autologous cells might be devised.

  • How to obtain enough of the right type of cells under good manufacturing practices (GMP) conditions.

  • How to deliver them to a large enough region to be therapeutically useful.

  • How to promote survival and integration of the transplanted cells.

  • How to ensure that transplanted cells do not result in tumor formation.